Selenium and vitamin E supplementation are unlikely to affect age-related cataract development in older men, according to an article published online September 18 in JAMA Ophthalmology.

William G. Christen, ScD, from the Division of Preventive Medicine and the Division of Medicine at Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, and colleagues conducted an ancillary study within the Selenium and Vitamin E Cancer Prevention Trial (SELECT) Eye Endpoints (SEE) Study.

The SELECT was a 4-group, phase 3, randomized placebo-controlled trial of selenium, vitamin E, and a combination of selenium and vitamin E for the prevention of prostate cancer in 35,533 men, beginning in 2001. The SEE trial involved a subset of 11,267 men, beginning in 2003, excluding men with a prior diagnosis of cataract at baseline.